Zheng Wang
Research interests:MRI, nonhuman primate models, psychiatric disorders, neuromodulation techniques
Address:Rm 336, LUI Che Woo Blding, Peking University
Email:zheng.wang(at)pku(dot)edu(dot)cn
Research Objective
Our lab mainly focuses on integrating advanced MRI methods with network computation and neuromodulation techniques to investigate the neuropathological and therapeutic mechanisms of psychiatric disorders such as addiction, obsessive-compulsive disorder in both human patients and monkey models. We are currently looking for talented graduate students and postdocs with professional training in cognitive/systems neuroscience, psychology, mathematics, MRI physics, computer science or appropriate engineering disciplines.
Selected publications (2015 - )
1. Qin DD1, Zhou JK1, He XC1, Shen XY1, Li C, Chen HZ, Yan LZ, Hu ZF, Li X, Lv LB, Yao YG*, Wang Z.*, Huang XX*, Hu XT*, Zheng P*, Depletion of giant ANK2 in monkeys causes drastic brain volume loss, Cell Discovery, 2021, in press.
2. Zhang CC1, Kim S-G1, Li J, Zhang YY, Lv QM, Zeljic K, Gong HF, Wei HG, Liu WJ, Sun BM, Wang Z*, Voon V*., Anterior limb of the internal capsule tractography: relationship with capsulotomy outcomes in obsessive-compulsive disorder, Journal of Neurology, Neurosurgery, and Psychiatry, 2021, in press.
4. Lv QM, Yan MC, Shen XY, Wu J, Yu WW, Yan SY, Yang F, Zeljic K, Shi YQ, Zhou ZF, Lv LB, Hu XT, Menon R, Wang Z.*, Normative analysis of individual brain differences based on a population MRI-based atlas of cynomolgus macaques, Cerebral Cortex, 2021, 31(1): 341-355.
6. Yin DZ1, Zhang CC1, Lv QM, Chen XY, Zeljic K, Gong HF, Zhan SK, Jin HY, Wang Z.*, Sun BM*, Dissociable frontostriatal connectivity: mechanism and predictor of the clinical efficacy of capsulotomy in obsessive-compulsive disorder, Biological Psychiatry, 2018, 84(12): 926-936. [Commentary by Hoexter MQ, Are we ready for individualized target planning of ablative procedures in intractable obsessive-compulsive disorder? Biological Psychiatry, 2018, 84(12): e85-e87]
7. Lv QM1, Wang Z1, Zhang CC1, Fan Q, Zeljic K, Sun BM, Xiao ZP*, Wang Z.*, Divergent structural responses to pharmacological interventions in orbitofronto-striato-thalamic and premotor circuits in obsessive-compulsive disorder, EBioMedicine, 2017, 22:242-248.
8. Zhou TT1, Zhu H1, Fan ZX, Wang F, Chen Y, Liang HX, Yang ZF, Zhang L, Lin LN, Zhan Y, Wang Z, Hu H*, History of winning remodels thalamo-PFC circuit to reinforce social dominance, Science, 2017, 357: 162-168.
9. Yin DZ, Liu WJ, Zeljic K, Wang ZW, Lv Q, Fan MX, Cheng WH*, Wang Z*, Dissociable changes of frontal and parietal cortices in inherent functional flexibility across the human lifespan, Journal of Neuroscience, 2016, 36(39):10060-10074.
10. Lv Q1, Yang LQ1, Li GL, Wang ZW, Shen ZM, Yu WW, Jiang QY, Hou BY, Pu J, Hu H*, Wang Z.*, Large-scale persistent network reconfiguration induced by ketamine in anesthetized macaques: relevance to mood disorders, Biological Psychiatry, 2016, 79: 765-775. [Commentary by Arnsten AF, Murray JD, Seo H, and Lee D. Ketamine’s antidepressant actions: potential mechanisms in the primate medial prefrontal circuits that represent aversive experience, Biological Psychiatry, 2016, 79: 713-715]
11. Pu J, Wang J, Yu WW, Shen ZM, Lv Q, Zeljic K, Zhang CC, Sun BM, Liu GX, Wang Z.*. Discriminative structured feature engineering for macroscale brain connectomes, IEEE Trans Med Imaging, 2015, 34(11):2333-2342.